|
rs9904341
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the SNP of rs9904341C/G in survivin may be correlated with the risk of acute leukemia, and compared with C/C genotype, patients with C/G or G/G may have a decreased risk of acute leukemia.
|
29456699 |
2018 |
|
rs927698341
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we aimed to evaluate the association between genotype or allele of CYP2B6 516G>T SNP and acute leukemia and myelodysplastic syndrome (MDS).
|
20878158 |
2011 |
|
rs8073069
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In survivin, rs8073069C/G may have no correlation with the risk of acute leukemia.
|
29456699 |
2018 |
|
rs80338880
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We studied the prevalence of 12 hereditary hemochromatosis (HH) gene mutations (C282Y, V53M, V59M, H63D, H63H, S56C, Q127H, E168Q, E168X, W169X and Q283P in the HFE gene and Y250X in the TFR2 gene) and its correlation with the iron status in 82 adult patients with acute leukemia (AL); 48 patients (58.5%) were affected by acute myeloid leukemia (AML) and 34 patients (41.5%) by acute lymphoblastic leukemia (ALL); 27 patients (32.9%) had at least one HH gene mutation (6 heterozygous for C282Y, 6 homozygous for H63D, 13 heterozygous for H63D and 2 heterozygous for S56C).
|
15863206 |
2005 |
|
rs797045145
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We studied the prevalence of 12 hereditary hemochromatosis (HH) gene mutations (C282Y, V53M, V59M, H63D, H63H, S56C, Q127H, E168Q, E168X, W169X and Q283P in the HFE gene and Y250X in the TFR2 gene) and its correlation with the iron status in 82 adult patients with acute leukemia (AL); 48 patients (58.5%) were affected by acute myeloid leukemia (AML) and 34 patients (41.5%) by acute lymphoblastic leukemia (ALL); 27 patients (32.9%) had at least one HH gene mutation (6 heterozygous for C282Y, 6 homozygous for H63D, 13 heterozygous for H63D and 2 heterozygous for S56C).
|
15863206 |
2005 |
|
rs780246573
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We studied the prevalence of 12 hereditary hemochromatosis (HH) gene mutations (C282Y, V53M, V59M, H63D, H63H, S56C, Q127H, E168Q, E168X, W169X and Q283P in the HFE gene and Y250X in the TFR2 gene) and its correlation with the iron status in 82 adult patients with acute leukemia (AL); 48 patients (58.5%) were affected by acute myeloid leukemia (AML) and 34 patients (41.5%) by acute lymphoblastic leukemia (ALL); 27 patients (32.9%) had at least one HH gene mutation (6 heterozygous for C282Y, 6 homozygous for H63D, 13 heterozygous for H63D and 2 heterozygous for S56C).
|
15863206 |
2005 |
|
rs777017502
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K</span>-transduced primary hematopoietic progenitor cells developed acute leukemia (latency of 68, 77, and 273 days), while no hematological malignancy was observed in the control groups including FLT3-ITD.
|
26891877 |
2016 |
|
rs77375493
|
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
JAK2 V617F mutation was detected after transformation to CMML in 1 of them; in the other, a novel translocation t(5;12)(p13;q24) was observed at the time of progression to acute leukemia.
|
21658659 |
2011 |
|
rs77375493
|
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
|
16037387 |
2005 |
|
rs77375493
|
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
A high JAK2(V617F) allele burden was correlated with the transformation to myelofibrosis (p<0.0001), but not with the transformation to acute leukemia.
|
22818858 |
2013 |
|
rs767464424
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K</span>-transduced primary hematopoietic progenitor cells developed acute leukemia (latency of 68, 77, and 273 days), while no hematological malignancy was observed in the control groups including FLT3-ITD.
|
26891877 |
2016 |
|
rs759834365
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism may contribute to development of depressive symptomatology in patients undergoing stressful life events, such as diagnosis of acute leukemia and preparation for HSCT.
|
22652301 |
2013 |
|
rs751689316
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Collaboration between AML1-D171N and Evi1 was confirmed by a BMT model where coexpression of AML1-D171N and Evi1 induced acute leukemia of the same phenotype with much shorter latencies.
|
18192504 |
2008 |
|
rs6265
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism may contribute to development of depressive symptomatology in patients undergoing stressful life events, such as diagnosis of acute leukemia and preparation for HSCT.
|
22652301 |
2013 |
|
rs62527607
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Evaluation of rs62527607 [GT] single nucleotide polymorphism located in BAALC gene in children with acute leukemia using mismatch PCR-RFLP.
|
27372260 |
2017 |
|
rs562015640
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, Ptpn11(E76K) mutation has non-lineage-specific effects on malignant transformation of hematopoietic cells and initiates acute leukemias at various stages of hematopoiesis.
|
21930766 |
2011 |
|
rs559063155
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patient samples showed SF3B1 K700E mutations within the ptDNA of 4 patients with acute leukemia and 3 with myelodysplastic syndrome who were known to harbor this mutation.
|
28615231 |
2017 |
|
rs4986791
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed 154 patients after allogeneic HSCT for acute leukemia for TLR4 gene variants 1063A/G (D299G) and 1363C/T (T399I) with their respective donors, and correlated the results with the incidence of invasive aspergillosis (IA) infection after transplant.
|
23890253 |
2013 |
|
rs4986790
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed 154 patients after allogeneic HSCT for acute leukemia for TLR4 gene variants 1063A/G (D299G) and 1363C/T (T399I) with their respective donors, and correlated the results with the incidence of invasive aspergillosis (IA) infection after transplant.
|
23890253 |
2013 |
|
rs4132601
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
For rs4132601 polymorphism, significantly increased AL risk was observed in all genetic models (the association was still significant when the p value was Bonferroni adjusted to 0.025).
|
25423013 |
2014 |
|
rs397514606
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrated that the AKT1 E17K mutation occurs in breast cancers at a low frequency, and that it is rare in other common cancers, including colorectal, lung, gastric and hepatocellular carcinomas and acute leukaemias.
|
18392055 |
2008 |
|
rs397507444
|
|
Acute leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in the Korean population.
|
17970089 |
2007 |
|
rs397507444
|
|
Acute leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.
|
22706675 |
2012 |
|
rs387906659
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrated that the AKT1 E17K mutation occurs in breast cancers at a low frequency, and that it is rare in other common cancers, including colorectal, lung, gastric and hepatocellular carcinomas and acute leukaemias.
|
18392055 |
2008 |
|
rs3745274
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we aimed to evaluate the association between genotype or allele of CYP2B6 516G>T SNP and acute leukemia and myelodysplastic syndrome (MDS).
|
20878158 |
2011 |